› 3ii7

X-ray diffraction
1.63Å resolution

Crystal structure of the kelch domain of human KLHL7

Released:
DOI: 10.2210/pdb3ii7/pdb
PDB entry 3ii7 coloured by chain, front view.
PDB entry 3ii7 coloured by chain, side view.
PDB entry 3ii7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.
Canning P, Cooper CDO, Krojer T, Murray JW, Pike ACW, Chaikuad A, Keates T, Thangaratnarajah C, Hojzan V, Marsden BD, Gileadi O, Knapp S, von Delft F, Bullock AN
J Biol Chem 288 7803-7814 (2013)
PMID: 23349464

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184921 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kelch-like protein 7 Chain: A
Molecule details ›
Chain: A
Length: 306 amino acids
Theoretical weight: 34.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IXQ5 (Residues: 283-586; Coverage: 52%)
Gene name: KLHL7
Sequence domains: Kelch motif
Structure domains: Kelch-type beta propeller

Ligands and Environments

1 bound ligand:
Ligand EDO 25 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: C2
Unit cell:
a: 76.435Å b: 50.905Å c: 87.5Å
α: 90° β: 113.19° γ: 90°
R-values:
R R work R free
0.163 0.161 0.19
Expression system: Escherichia coli

Quick links

Citations

44 review citations

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis.
Yamamoto et al. (2018)
43 more

8 mentions without citation

Challenges and Limitations of Targeting the Keap1-Nrf2 Pathway for Neurotherapeutics: Bach1 De-Repression to the Rescue.
Hushpulian et al. (2021)
7 more