› 3im6

X-ray diffraction
1.7Å resolution

Crystal structure of mouse Ryanodine Receptor 2 mutant V186M

Released:
DOI: 10.2210/pdb3im6/pdb
PDB entry 3im6 coloured by chain, front view.
PDB entry 3im6 coloured by chain, side view.
PDB entry 3im6 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structures of the N-terminal domains of cardiac and skeletal muscle ryanodine receptors: insights into disease mutations.
Lobo PA, Van Petegem F
Structure 17 1505-14 (2009)
PMID: 19913485

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-123214 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ryanodine receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 217 amino acids
Theoretical weight: 24.2 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: E9Q401 (Residues: 1-217; Coverage: 4%)
Gene name: Ryr2
Sequence domains: Inositol 1,4,5-trisphosphate/ryanodine receptor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: I41
Unit cell:
a: 112.512Å b: 112.512Å c: 36.751Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.201 0.244
Expression system: Escherichia coli

Quick links

Citations

22 review citations

Ryanodine receptors: structure, expression, molecular details, and function in calcium release.
Lanner et al. (2010)
21 more

2 mentions without citation

Structural Insight Into Ryanodine Receptor Channelopathies.
Hadiatullah et al. (2022)
1 more