› 3ing

X-ray diffraction
1.95Å resolution

Crystal structure of Homoserine dehydrogenase (NP_394635.1) from THERMOPLASMA ACIDOPHILUM at 1.95 A resolution

Released:
DOI: 10.2210/pdb3ing/pdb
PDB entry 3ing coloured by chain, front view.
PDB entry 3ing coloured by chain, side view.
PDB entry 3ing coloured by chain, top view.
Source organism: Thermoplasma acidophilum
Entry author: Joint Center for Structural Genomics (JCSG)

Function and Biology Details

Reaction catalysed: 
L-homoserine + NAD(P)(+) = L-aspartate 4-semialdehyde + NAD(P)H
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190846 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
homoserine dehydrogenase Chain: A
Molecule details ›
Chain: A
Length: 325 amino acids
Theoretical weight: 36.13 KDa
Source organism: Thermoplasma acidophilum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9HIZ7 (Residues: 1-324; Coverage: 100%)
Gene name: Ta1179
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand NDP 1 x NDP
2 bound ligands:
Ligand NA 1 x NA
Ligand EDO 6 x EDO
1 modified residue:
Ligand MSE 9 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: C2221
Unit cell:
a: 69.821Å b: 92.113Å c: 120.788Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.154 0.152 0.193
Expression system: Escherichia coli

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