› 3inu

X-ray diffraction
2.5Å resolution

Crystal structure of an unbound KZ52 neutralizing anti-Ebolavirus antibody.

Released:
DOI: 10.2210/pdb3inu/pdb
PDB entry 3inu coloured by chain, front view.
PDB entry 3inu coloured by chain, side view.
PDB entry 3inu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Techniques and tactics used in determining the structure of the trimeric ebolavirus glycoprotein.
Lee JE, Fusco ML, Abelson DM, Hessell AJ, Burton DR, Saphire EO
Acta Crystallogr D Biol Crystallogr 65 1162-80 (2009)
PMID: 19923712

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213290 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
KZ52 antibody fragment heavy chain Chains: H, M
Molecule details ›
Chains: H, M
Length: 226 amino acids
Theoretical weight: 24.02 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins
KZ52 antibody fragment light chain Chains: L, N
Molecule details ›
Chains: L, N
Length: 217 amino acids
Theoretical weight: 23.9 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand SO4 8 x SO4
Ligand GOL 4 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P3221
Unit cell:
a: 129.52Å b: 129.52Å c: 184.96Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.205 0.203 0.252
Expression system: Cricetulus griseus

Quick links

Citations

3 review citations

Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: an update for 2009-2010.
Harvey DJ. (2015)
2 more

4 mentions without citation

Max Bergmann lecture protein epitope mimetics in the age of structural vaccinology.
Robinson JA. (2013)
3 more