› 3ix4

X-ray diffraction
1.8Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150367 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcriptional activator protein LasR Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 173 amino acids
Theoretical weight: 19.32 KDa
Source organism: Pseudomonas aeruginosa
Expression system: Escherichia coli
UniProt:
  • Canonical: P25084 (Residues: 1-173; Coverage: 72%)
Gene names: PA1430, lasR
Sequence domains: Autoinducer binding domain
Structure domains: Transcription factor LuxR-like, autoinducer-binding domain

Ligands and Environments

1 bound ligand:
Ligand TX1 8 x TX1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P21
Unit cell:
a: 54.196Å b: 84.546Å c: 156.385Å
α: 90° β: 95.97° γ: 90°
R-values:
R R work R free
0.201 0.199 0.247
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Exploiting quorum sensing to confuse bacterial pathogens.
LaSarre et al. (2013)
8 more

9 mentions without citation

Structure-based Druggability Assessment of Anti-virulence Targets from Pseudomonas aeruginosa.
Froes et al. (2019)
8 more