› 3ixt

X-ray diffraction
2.75Å resolution

Crystal Structure of Motavizumab Fab Bound to Peptide Epitope

Released:
DOI: 10.2210/pdb3ixt/pdb
PDB entry 3ixt coloured by chain, front view.
PDB entry 3ixt coloured by chain, side view.
PDB entry 3ixt coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis of respiratory syncytial virus neutralization by motavizumab.
McLellan JS, Chen M, Kim A, Yang Y, Graham BS, Kwong PD
Nat Struct Mol Biol 17 248-50 (2010)
PMID: 20098425

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208920 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Motavizumab Fab light chain Chains: B, L
Molecule details ›
Chains: B, L
Length: 213 amino acids
Theoretical weight: 23.15 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Motavizumab Fab heavy chain Chains: A, H
Molecule details ›
Chains: A, H
Length: 225 amino acids
Theoretical weight: 24.28 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Fusion glycoprotein F1 Chains: C, P
Molecule details ›
Chains: C, P
Length: 26 amino acids
Theoretical weight: 2.76 KDa
Source organism: Human respiratory syncytial virus A2
UniProt:
  • Canonical: P03420 (Residues: 253-277; Coverage: 5%)
Gene name: F

Ligands and Environments

1 bound ligand:
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P43212
Unit cell:
a: 90.752Å b: 90.752Å c: 232.057Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.213 0.274
Expression system: Homo sapiens

Quick links

Citations

18 review citations

Progress in understanding and controlling respiratory syncytial virus: still crazy after all these years.
Collins et al. (2011)
17 more

28 mentions without citation

Max Bergmann lecture protein epitope mimetics in the age of structural vaccinology.
Robinson JA. (2013)
27 more