› 3j0a

Electron Microscopy
26Å resolution

Homology model of human Toll-like receptor 5 fitted into an electron microscopy single particle reconstruction

Released:
DOI: 10.2210/pdb3j0a/pdb
PDB entry 3j0a coloured by chain, front view.
PDB entry 3j0a coloured by chain, side view.
PDB entry 3j0a coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Toll-like receptor 5 forms asymmetric dimers in the absence of flagellin.
Zhou K, Kanai R, Lee P, Wang HW, Modis Y
J Struct Biol 177 402-9 (2012)
PMID: 22173220
Related structures: EMD-5287

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130041 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Toll-like receptor 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 844 amino acids
Theoretical weight: 96.66 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O60602 (Residues: 23-858; Coverage: 100%)
Gene names: TIL3, TLR5
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 26Å
Relevant EMDB volumes: EMD-5287
Expression system: Spodoptera frugiperda

Quick links

Citations

8 review citations

Toll/interleukin-1 receptor (TIR) domain-mediated cellular signaling pathways.
Narayanan et al. (2015)
7 more

44 mentions without citation

Structure of fish Toll-like receptors (TLR) and NOD-like receptors (NLR).
Sahoo BR. (2020)
43 more