› 3j2w

Electron Microscopy
5Å resolution

Electron cryo-microscopy of Chikungunya virus

Released:
DOI: 10.2210/pdb3j2w/pdb
PDB entry 3j2w coloured by chain, front view.
PDB entry 3j2w coloured by chain, side view.
PDB entry 3j2w coloured by chain, top view.
Source organism: Chikungunya virus strain Senegal 37997
Primary publication:
Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization.
Sun S, Xiang Y, Akahata W, Holdaway H, Pal P, Zhang X, Diamond MS, Nabel GJ, Rossmann MG
Elife 2 e00435 (2013)
PMID: 23577234
Related structures: EMD-5577

Function and Biology Details

Reaction catalysed: 
Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp-|-Ser- bond.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 1200-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172871 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
p130 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 393 amino acids
Theoretical weight: 42.71 KDa
Source organism: Chikungunya virus strain Senegal 37997
Expression system: Homo sapiens
UniProt:
  • Canonical: Q1H8W5 (Residues: 810-1202; Coverage: 32%)
Sequence domains: Alphavirus E1 glycoprotein
p130 Chains: M, N, O
Molecule details ›
Chains: M, N, O
Length: 336 amino acids
Theoretical weight: 37.85 KDa
Source organism: Chikungunya virus strain Senegal 37997
Expression system: Homo sapiens
UniProt:
  • Canonical: Q1H8W5 (Residues: 332-667; Coverage: 27%)
Sequence domains: Alphavirus E2 glycoprotein
p130 Chain: P
Molecule details ›
Chain: P
Length: 336 amino acids
Theoretical weight: 37.87 KDa
Source organism: Chikungunya virus strain Senegal 37997
Expression system: Homo sapiens
UniProt:
  • Canonical: Q1H8W5 (Residues: 332-667; Coverage: 27%)
Sequence domains: Alphavirus E2 glycoprotein
Spike glycoprotein E1 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 46 amino acids
Theoretical weight: 4.81 KDa
Source organism: Chikungunya virus strain Senegal 37997
Expression system: Homo sapiens
UniProt:
  • Canonical: Q5XXP3 (Residues: 1203-1248; Coverage: 4%)
Spike glycoprotein E2 Chains: Q, R, S, T
Molecule details ›
Chains: Q, R, S, T
Length: 81 amino acids
Theoretical weight: 8.82 KDa
Source organism: Chikungunya virus strain Senegal 37997
Expression system: Homo sapiens
UniProt:
  • Canonical: Q5XXP3 (Residues: 668-748; Coverage: 7%)
Capsid protein Chains: I, J, K, L
Molecule details ›
Chains: I, J, K, L
Length: 149 amino acids
Theoretical weight: 16.23 KDa
Source organism: Chikungunya virus strain Senegal 37997
Expression system: Homo sapiens
UniProt:
  • Canonical: Q5XXP3 (Residues: 113-261; Coverage: 12%)
Sequence domains: Alphavirus core protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 5Å
Relevant EMDB volumes: EMD-5577
Expression system: Homo sapiens

Quick links

Citations

20 review citations

Early Events in Chikungunya Virus Infection-From Virus Cell Binding to Membrane Fusion.
van Duijl-Richter et al. (2015)
19 more

30 mentions without citation

Alphavirus Virulence Determinants.
Rangel et al. (2021)
29 more