Function and Biology Details
Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero octamer (preferred)
Assembly name:
Proteasome complex (preferred)
PDBe Complex ID:
PDB-CPX-152330 (preferred)
Entry contents:
8 distinct polypeptide molecules
Macromolecules (8 distinct):
Ubiquitin carboxyl-terminal hydrolase RPN11
Molecule details ›
Chain: V
Length: 69 amino acids
Theoretical weight: 8.01 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
Length: 69 amino acids
Theoretical weight: 8.01 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
- Canonical:
P43588 (Residues: 230-298; Coverage: 23%)
26S proteasome regulatory subunit RPN8
Molecule details ›
Chain: U
Length: 121 amino acids
Theoretical weight: 13.97 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
Sequence domains: Maintenance of mitochondrial structure and function
Length: 121 amino acids
Theoretical weight: 13.97 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
- Canonical: Q08723 (Residues: 188-308; Coverage: 36%)
Sequence domains: Maintenance of mitochondrial structure and function
26S proteasome regulatory subunit RPN9
Molecule details ›
Chain: O
Length: 28 amino acids
Theoretical weight: 3.35 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
Sequence domains: Rpn9 C-terminal helix
Length: 28 amino acids
Theoretical weight: 3.35 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
- Canonical: Q04062 (Residues: 360-387; Coverage: 7%)
Sequence domains: Rpn9 C-terminal helix
26S proteasome regulatory subunit RPN5
Molecule details ›
Chain: P
Length: 34 amino acids
Theoretical weight: 3.98 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
Sequence domains: 26S proteasome regulatory subunit RPN5 C-terminal domain
Length: 34 amino acids
Theoretical weight: 3.98 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
- Canonical: Q12250 (Residues: 409-442; Coverage: 8%)
Sequence domains: 26S proteasome regulatory subunit RPN5 C-terminal domain
26S proteasome regulatory subunit RPN6
Molecule details ›
Chain: Q
Length: 25 amino acids
Theoretical weight: 2.74 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
Sequence domains: 26S proteasome subunit RPN6 C-terminal helix domain
Length: 25 amino acids
Theoretical weight: 2.74 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
- Canonical: Q12377 (Residues: 407-431; Coverage: 6%)
Sequence domains: 26S proteasome subunit RPN6 C-terminal helix domain
26S proteasome regulatory subunit RPN7
Molecule details ›
Chain: R
Length: 26 amino acids
Theoretical weight: 2.89 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
Sequence domains: 26S proteasome regulatory subunit RPN7/PSMD6 C-terminal helix
Length: 26 amino acids
Theoretical weight: 2.89 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
- Canonical: Q06103 (Residues: 397-422; Coverage: 6%)
Sequence domains: 26S proteasome regulatory subunit RPN7/PSMD6 C-terminal helix
26S proteasome regulatory subunit RPN3
Molecule details ›
Chain: S
Length: 24 amino acids
Theoretical weight: 2.92 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
Sequence domains: Proteasome regulatory subunit C-terminal
Length: 24 amino acids
Theoretical weight: 2.92 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
- Canonical: P40016 (Residues: 455-478; Coverage: 5%)
Sequence domains: Proteasome regulatory subunit C-terminal
26S proteasome regulatory subunit RPN12
Molecule details ›
Chain: T
Length: 17 amino acids
Theoretical weight: 1.96 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
Length: 17 amino acids
Theoretical weight: 1.96 KDa
Source organism: Saccharomyces cerevisiae S288C
UniProt:
- Canonical: P32496 (Residues: 256-272; Coverage: 6%)
