› 3j9p

Electron Microscopy
4.24Å resolution

Structure of the TRPA1 ion channel determined by electron cryo-microscopy

Released:
DOI: 10.2210/pdb3j9p/pdb
PDB entry 3j9p coloured by chain, front view.
PDB entry 3j9p coloured by chain, side view.
PDB entry 3j9p coloured by chain, top view.
Source organisms:
Primary publication:
Structure of the TRPA1 ion channel suggests regulatory mechanisms.
Paulsen CE, Armache JP, Gao Y, Cheng Y, Julius D
Nature 520 511-7 (2015)
PMID: 25855297
Related structures: EMD-6267

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131114 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Maltose/maltodextrin-binding periplasmic protein; Transient receptor potential cation channel subfamily A member 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1528 amino acids
Theoretical weight: 172.58 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P0AEX9 (Residues: 27-392; Coverage: 99%)
  • Canonical: O75762 (Residues: 2-1119; Coverage: 100%)
Gene names: ANKTM1, JW3994, TRPA1, b4034, malE
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.24Å
Relevant EMDB volumes: EMD-6267
Expression system: Homo sapiens

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Citations

85 review citations

Oxidative Stress in Cancer.
Hayes et al. (2020)
84 more

73 mentions without citation

Cannabinoid Ligands Targeting TRP Channels.
Muller et al. (2018)
72 more