› 3jav

Electron Microscopy
4.7Å resolution

Structure of full-length IP3R1 channel in the apo-state determined by single particle cryo-EM

Released:
DOI: 10.2210/pdb3jav/pdb
PDB entry 3jav coloured by chain, front view.
PDB entry 3jav coloured by chain, side view.
PDB entry 3jav coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Gating machinery of InsP3R channels revealed by electron cryomicroscopy.
Fan G, Baker ML, Wang Z, Baker MR, Sinyagovskiy PA, Chiu W, Ludtke SJ, Serysheva II
Nature 527 336-41 (2015)
PMID: 26458101
Related structures: EMD-6369

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151603 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 2750 amino acids
Theoretical weight: 313.66 KDa
Source organism: Rattus norvegicus
UniProt:
  • Canonical: P29994 (Residues: 1-2750; Coverage: 100%)
Gene names: Insp3r, Itpr1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 4.7Å
Relevant EMDB volumes: EMD-6369

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Citations

37 review citations

Unravelling biological macromolecules with cryo-electron microscopy.
Fernandez-Leiro et al. (2016)
36 more

23 mentions without citation

Ca2+ Release Channels Join the 'Resolution Revolution'.
Zalk et al. (2017)
22 more