3jc2

Electron Microscopy
3.6Å resolution

The structure of the mammalian Sec61 channel opened by a signal sequence

Released:
Primary publication:
Structure of the Sec61 channel opened by a signal sequence.
Science 351 88-91 (2016)
PMID: 26721998
Related structures: EMD-3245

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-134125 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Protein transport protein Sec61 subunit alpha isoform 1 Chain: 1
Molecule details ›
Chain: 1
Length: 476 amino acids
Theoretical weight: 52.28 KDa
Source organism: Canis lupus familiaris
UniProt:
  • Canonical: P38377 (Residues: 1-476; Coverage: 100%)
Gene name: SEC61A1
Sequence domains:
Protein transport protein Sec61 subunit gamma Chain: 2
Molecule details ›
Chain: 2
Length: 62 amino acids
Theoretical weight: 7.02 KDa
Source organism: Canis lupus familiaris
UniProt:
  • Canonical: P60058 (Residues: 7-68; Coverage: 91%)
Gene name: SEC61G
Sequence domains: SecE/Sec61-gamma subunits of protein translocation complex
Structure domains: Preprotein translocase SecE subunit
Prolactin Chain: w
Molecule details ›
Chain: w
Length: 19 amino acids
Theoretical weight: 2.05 KDa
Source organism: Bos taurus
Expression system: Oryctolagus cuniculus
UniProt:
  • Canonical: P01239 (Residues: 12-30; Coverage: 0%)
Gene name: PRL
Protein transport protein Sec61 subunit beta Chain: 3
Molecule details ›
Chain: 3
Length: 32 amino acids
Theoretical weight: 2.74 KDa
Source organism: Canis lupus familiaris

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-3245
Expression system: Oryctolagus cuniculus