› 3jpy

X-ray diffraction
3.21Å resolution

Crystal structure of the zinc-bound amino terminal domain of the NMDA receptor subunit NR2B

Released:
DOI: 10.2210/pdb3jpy/pdb
PDB entry 3jpy coloured by chain, front view.
PDB entry 3jpy coloured by chain, side view.
PDB entry 3jpy coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit.
Karakas E, Simorowski N, Furukawa H
EMBO J 28 3910-20 (2009)
PMID: 19910922

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-169492 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, NMDA 2B Chain: A
Molecule details ›
Chain: A
Length: 363 amino acids
Theoretical weight: 41.28 KDa
Source organism: Rattus norvegicus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q00960 (Residues: 32-394; Coverage: 25%)
Gene name: Grin2b
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold

Ligands and Environments

4 bound ligands:
Ligand NAG 2 x NAG
Ligand CL 5 x CL
Ligand NA 1 x NA
Ligand ZN 5 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P3121
Unit cell:
a: 143.368Å b: 143.368Å c: 88.467Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.204 0.233
Expression system: Trichoplusia ni

Quick links

Citations

38 review citations

Molecular basis of NMDA receptor functional diversity.
Paoletti P. (2011)
37 more

12 mentions without citation

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
11 more