› 3jvj

X-ray diffraction
1.55Å resolution

Crystal structure of the bromodomain 1 in mouse Brd4

Released:
DOI: 10.2210/pdb3jvj/pdb
PDB entry 3jvj coloured by chain, front view.
PDB entry 3jvj coloured by chain, side view.
PDB entry 3jvj coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structures of the dual bromodomains of the P-TEFb-activating protein Brd4 at atomic resolution.
Vollmuth F, Blankenfeldt W, Geyer M
J Biol Chem 284 36547-36556 (2009)
PMID: 19828451

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190194 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 4 Chain: A
Molecule details ›
Chain: A
Length: 131 amino acids
Theoretical weight: 15.39 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9ESU6 (Residues: 42-168; Coverage: 9%)
Gene names: Brd4, Mcap
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

2 bound ligands:
Ligand GOL 1 x GOL
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 34.014Å b: 47.442Å c: 78.024Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.184 0.219
Expression system: Escherichia coli

Quick links

Citations

26 review citations

Small-molecule inhibitors of protein-protein interactions: progressing toward the reality.
Arkin et al. (2014)
25 more

1 mention without citation

Structures of the dual bromodomains of the P-TEFb-activating protein Brd4 at atomic resolution.
Vollmuth et al. (2009)