› 3jwp

X-ray diffraction
2.65Å resolution

Crystal structure of Plasmodium falciparum SIR2A (PF13_0152) in complex with AMP

Released:
DOI: 10.2210/pdb3jwp/pdb
Model geometry
Fit model/data
PDB entry 3jwp coloured by chain, front view.
PDB entry 3jwp coloured by chain, side view.
PDB entry 3jwp coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Entry authors: Wernimont AK, Hutchinson A, Lin YH, MacKenzie F, Senisterra G, Allali-Hassanali A, Vedadi M, Ravichandran M, Cossar D, Kozieradzki I, Zhao Y, Schapira M, Arrowsmith CH, Bountra C, Weigelt J, Edwards AM, Hui R, Qiu W, Brand V, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184752 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NAD-dependent protein deacylase Sir2A Chain: A
Molecule details ›
Chain: A
Length: 265 amino acids
Theoretical weight: 29.62 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IE47 (Residues: 10-273; Coverage: 97%)
Gene names: PF13_0152, PF3D7_1328800, Sir2, Sir2A
Sequence domains: Sir2 family
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand AMP 1 x AMP
Ligand ZN 1 x ZN
Ligand PGE 1 x PGE
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: CHESS BEAMLINE A1
Spacegroup: P6
Unit cell:
a: 106.564Å b: 106.564Å c: 44.968Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.209 0.206 0.274
Expression system: Escherichia coli

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