› 3jz7

X-ray diffraction
2.19Å resolution

Crystal structure of the extracellular domains of coxsackie & adenovirus receptor from mouse (mCAR)

Released:
DOI: 10.2210/pdb3jz7/pdb
PDB entry 3jz7 coloured by chain, front view.
PDB entry 3jz7 coloured by chain, side view.
PDB entry 3jz7 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The coxsackievirus-adenovirus receptor reveals complex homophilic and heterophilic interactions on neural cells.
Patzke C, Max KE, Behlke J, Schreiber J, Schmidt H, Dorner AA, Kröger S, Henning M, Otto A, Heinemann U, Rathjen FG
J Neurosci 30 2897-910 (2010)
PMID: 20181587

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161326 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Coxsackievirus and adenovirus receptor homolog Chain: A
Molecule details ›
Chain: A
Length: 214 amino acids
Theoretical weight: 23.73 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P97792 (Residues: 20-233; Coverage: 62%)
Gene names: Car, Cxadr
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand IPA 2 x IPA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P21212
Unit cell:
a: 53.369Å b: 61.468Å c: 86.355Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.209 0.265
Expression system: Escherichia coli BL21

Quick links

Citations

10 review citations

JAM-related proteins in mucosal homeostasis and inflammation.
Luissint et al. (2014)
9 more

7 mentions without citation

The Evolution of Gene Therapy in the Treatment of Metabolic Liver Diseases.
Moscoso et al. (2020)
6 more