› 3k7h

X-ray diffraction
1.5Å resolution

Crystal structure of the E95K mutant of the Indian Hedgehog N-terminal signalling domain

Released:
DOI: 10.2210/pdb3k7h/pdb
PDB entry 3k7h coloured by chain, front view.
PDB entry 3k7h coloured by chain, side view.
PDB entry 3k7h coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: He Y-X, Kang Y, Zhang WJ, Yu J, Ma G, Zhou C-Z

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172045 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Indian hedgehog protein N-product Chain: B
Molecule details ›
Chain: B
Length: 187 amino acids
Theoretical weight: 21.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14623 (Residues: 28-202; Coverage: 46%)
Gene name: IHH
Sequence domains: Hedgehog amino-terminal signalling domain
Structure domains: Muramoyl-pentapeptide Carboxypeptidase; domain 2

Ligands and Environments

2 bound ligands:
Ligand ZN 1 x ZN
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2
Unit cell:
a: 107.89Å b: 52.75Å c: 35.44Å
α: 90° β: 90.54° γ: 90°
R-values:
R R work R free
0.19 0.19 0.198
Expression system: Escherichia coli

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