› 3k7l

X-ray diffraction
2.5Å resolution

Structures of two elapid snake venom metalloproteases with distinct activities highlight the disulfide patterns in the D domain of ADAMalysin family proteins

Released:
DOI: 10.2210/pdb3k7l/pdb
PDB entry 3k7l coloured by chain, front view.
PDB entry 3k7l coloured by chain, side view.
PDB entry 3k7l coloured by chain, top view.
Source organism: Naja atra
Primary publication:
Structures of two elapid snake venom metalloproteases with distinct activities highlight the disulfide patterns in the D domain of ADAMalysin family proteins.
Guan HH, Goh KS, Davamani F, Wu PL, Huang YW, Jeyakanthan J, Wu WG, Chen CJ
J Struct Biol 169 294-303 (2010)
PMID: 19932752

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112551 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Zinc metalloproteinase-disintegrin-like atragin Chain: A
Molecule details ›
Chain: A
Length: 422 amino acids
Theoretical weight: 47.75 KDa
Source organism: Naja atra
UniProt:
  • Canonical: D3TTC2 (Residues: 192-613; Coverage: 71%)
Sequence domains:
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments

3 bound ligands:
Ligand NAG 1 x NAG
Ligand ZN 1 x ZN
Ligand CA 3 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1, SPRING-8 BEAMLINE BL12B2
Spacegroup: P43212
Unit cell:
a: 91.65Å b: 91.65Å c: 124.235Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.224 0.234

Quick links

Citations

6 review citations

Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases.
Escalante et al. (2011)
5 more

4 mentions without citation

ADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural Overview.
Takeda S. (2016)
3 more