› 3kaa

X-ray diffraction
3Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186593 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatitis A virus cellular receptor 2 homolog Chains: A, B
Molecule details ›
Chains: A, B
Length: 118 amino acids
Theoretical weight: 13.36 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8VIM0 (Residues: 21-133; Coverage: 43%)
Gene names: Havcr2, Tim3, Timd3
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand CA 1 x CA
Ligand PSF 1 x PSF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: R32
Unit cell:
a: 71.922Å b: 71.922Å c: 263.579Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.236 0.235 0.245
Expression system: Escherichia coli

Quick links

Citations

82 review citations

Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation.
Anderson et al. (2016)
81 more

10 mentions without citation

TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity.
Freeman et al. (2010)
9 more