› 3kbx

X-ray diffraction
2.65Å resolution

Human macrophage inflammatory protein-1 alpha L3M_V63M

Released:
DOI: 10.2210/pdb3kbx/pdb
PDB entry 3kbx coloured by chain, front view.
PDB entry 3kbx coloured by chain, side view.
PDB entry 3kbx coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Guo Q, Ren M, Tang W-J

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145189 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-C motif chemokine 3 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 70 amino acids
Theoretical weight: 7.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10147 (Residues: 23-92; Coverage: 100%)
Gene names: CCL3, G0S19-1, MIP1A, SCYA3
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

2 bound ligands:
Ligand K 1 x K
Ligand ACT 1 x ACT
1 modified residue:
Ligand MSE 10 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P6222
Unit cell:
a: 178.01Å b: 178.01Å c: 77.311Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.214 0.212 0.257
Expression system: Escherichia coli

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