› 3kg2

X-ray diffraction
3.6Å resolution

AMPA subtype ionotropic glutamate receptor in complex with competitive antagonist ZK 200775

Released:
DOI: 10.2210/pdb3kg2/pdb
PDB entry 3kg2 coloured by chain, front view.
PDB entry 3kg2 coloured by chain, side view.
PDB entry 3kg2 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor.
Sobolevsky AI, Rosconi MP, Gouaux E
Nature 462 745-56 (2009)
PMID: 19946266

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148611 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Glutamate receptor 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 823 amino acids
Theoretical weight: 92.04 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19491 (Residues: 25-847; Coverage: 95%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
1 bound ligand:
Ligand ZK1 4 x ZK1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P1
Unit cell:
a: 90.715Å b: 109.848Å c: 161.13Å
α: 85.32° β: 84.75° γ: 78.92°
R-values:
R R work R free
0.287 0.286 0.296
Expression system: Escherichia coli

Quick links

Citations

128 review citations

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease.
Paoletti et al. (2013)
127 more

145 mentions without citation

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
144 more