Function and Biology Details
Reactions catalysed:
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Thymidylate synthase
- Dihydrofolate reductase domain
- Thymidylate synthase/dCMP hydroxymethylase domain
- Thymidylate synthase/dCMP hydroxymethylase superfamily
- Dihydrofolate reductase-like domain superfamily
- Thymidylate synthase, active site
- Thymidylate synthase/dCMP hydroxymethylase
- Dihydrofolate reductase conserved site
1 more domain
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186128 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bifunctional dihydrofolate reductase-thymidylate synthase
Molecule details ›
Chains: A, B, C, D
Length: 521 amino acids
Theoretical weight: 58.9 KDa
Source organism: Trypanosoma cruzi
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains:
Length: 521 amino acids
Theoretical weight: 58.9 KDa
Source organism: Trypanosoma cruzi
Expression system: Escherichia coli
UniProt:
- Canonical:
Q8T5T8 (Residues: 1-521; Coverage: 100%)
Sequence domains:
Structure domains:
