Function and Biology Details
Reactions catalysed:
Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'.
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
NS4a protein (preferred)
PDBe Complex ID:
PDB-CPX-190145 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
HCV NS3 Protease
Molecule details ›
Chains: A, C
Length: 200 amino acids
Theoretical weight: 21.23 KDa
Source organism: Hepatitis C virus (isolate H77)
Expression system: Escherichia coli
UniProt:
Structure domains:
Length: 200 amino acids
Theoretical weight: 21.23 KDa
Source organism: Hepatitis C virus (isolate H77)
Expression system: Escherichia coli
UniProt:
- Canonical:
Q9ELS8 (Residues: 1027-1207; Coverage: 6%)
Structure domains:
HCV NS4a peptide
Molecule details ›
Chains: B, D
Length: 23 amino acids
Theoretical weight: 2.39 KDa
Source organism: hepatitis C virus genotype 1a
Expression system: Not provided
UniProt:
Length: 23 amino acids
Theoretical weight: 2.39 KDa
Source organism: hepatitis C virus genotype 1a
Expression system: Not provided
UniProt:
- Canonical: Q9ELS8 (Residues: 1678-1696; Coverage: 1%)
