› 3kqr

X-ray diffraction
1.5Å resolution

The structure of serum amyloid p component bound to phosphoethanolamine

Released:
DOI: 10.2210/pdb3kqr/pdb
PDB entry 3kqr coloured by chain, front view.
PDB entry 3kqr coloured by chain, side view.
PDB entry 3kqr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of ligand specificity in the human pentraxins, C-reactive protein and serum amyloid P component.
Mikolajek H, Kolstoe SE, Pye VE, Mangione P, Pepys MB, Wood SP
J Mol Recognit 24 371-7 (2011)
PMID: 21360619

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136123 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serum amyloid P-component Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 204 amino acids
Theoretical weight: 23.28 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02743 (Residues: 20-223; Coverage: 100%)
Gene names: APCS, PTX2
Sequence domains: Pentaxin family
Structure domains: Jelly Rolls

Ligands and Environments

3 bound ligands:
Ligand OPE 5 x OPE
Ligand CA 10 x CA
Ligand NAG 5 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P21
Unit cell:
a: 94.86Å b: 69.86Å c: 102.27Å
α: 90° β: 96.95° γ: 90°
R-values:
R R work R free
0.142 0.141 0.161

Quick links

Citations

12 review citations

Post-translational control of protein function by disulfide bond cleavage.
Cook et al. (2013)
11 more