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X-ray diffraction
1.55Å resolution

Structure of Triosephosphate Isomerase from Cryptosporidium Parvum at 1.55A Resolution

Released:
DOI: 10.2210/pdb3krs/pdb
PDB entry 3krs coloured by chain, front view.
PDB entry 3krs coloured by chain, side view.
PDB entry 3krs coloured by chain, top view.
Source organism: Cryptosporidium parvum Iowa II
Primary publication:
Structure of triosephosphate isomerase from Cryptosporidium parvum.
Nguyen TN, Abendroth J, Leibly DJ, Le KP, Guo W, Kelley A, Stewart L, Myler PJ, Van Voorhis WC
Acta Crystallogr Sect F Struct Biol Cryst Commun 67 1095-9 (2011)
PMID: 21904056

Function and Biology Details

Reaction catalysed: 
D-glyceraldehyde 3-phosphate = glycerone phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Triosephosphate isomerase Chains: A, B
Molecule details ›
Chains: A, B
Length: 271 amino acids
Theoretical weight: 29.7 KDa
Source organism: Cryptosporidium parvum Iowa II
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5CSE7 (Residues: 1-250; Coverage: 100%)
Gene name: cgd1_3040
Sequence domains: Triosephosphate isomerase
Structure domains: Aldolase class I

Ligands and Environments

2 bound ligands:
Ligand NA 2 x NA
Ligand UNX 12 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P21
Unit cell:
a: 53.56Å b: 71.93Å c: 75.83Å
α: 90° β: 106.47° γ: 90°
R-values:
R R work R free
0.159 0.157 0.188
Expression system: Escherichia coli

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Citations

1 citations in other articles

Therapeutic efficacy of proton pump inhibitor (omeprazole) on cryptosporidiosis parvum in immunosuppressed experimental mice.
Beshay et al. (2023)

2 mentions without citation

Stability tests on known and misfolded structures with discrete and all atom molecular dynamics simulations.
Yun et al. (2011)
1 more