› 3l1l

X-ray diffraction
3Å resolution

Structure of Arg-bound Escherichia coli AdiC

Released:
DOI: 10.2210/pdb3l1l/pdb
PDB entry 3l1l coloured by chain, front view.
PDB entry 3l1l coloured by chain, side view.
PDB entry 3l1l coloured by chain, top view.
Source organism: Escherichia coli O157:H7
Primary publication:
Mechanism of substrate recognition and transport by an amino acid antiporter.
Gao X, Zhou L, Jiao X, Lu F, Yan C, Zeng X, Wang J, Shi Y
Nature 463 828-32 (2010)
PMID: 20090677

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157971 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Arginine/agmatine antiporter Chain: A
Molecule details ›
Chain: A
Length: 445 amino acids
Theoretical weight: 46.9 KDa
Source organism: Escherichia coli O157:H7
Expression system: Escherichia coli
UniProt:
  • Canonical: P60063 (Residues: 1-445; Coverage: 100%)
Gene names: ECs5097, Z5717, adiC
Sequence domains: Amino acid permease

Ligands and Environments

2 bound ligands:
Ligand ARG 1 x ARG
Ligand BNG 1 x BNG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: I212121
Unit cell:
a: 84.69Å b: 127.17Å c: 157.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.222 0.279
Expression system: Escherichia coli

Quick links

Citations

24 review citations

SLC6 neurotransmitter transporters: structure, function, and regulation.
Kristensen et al. (2011)
23 more

46 mentions without citation

Insights into the Structure, Function, and Ligand Discovery of the Large Neutral Amino Acid Transporter 1, LAT1.
Singh et al. (2018)
45 more