› 3l1n

X-ray diffraction
1.3Å resolution

Crystal structure of Mp1p ligand binding domain 2 complexd with palmitic acid

Released:
DOI: 10.2210/pdb3l1n/pdb
PDB entry 3l1n coloured by chain, front view.
PDB entry 3l1n coloured by chain, side view.
PDB entry 3l1n coloured by chain, top view.
Source organism: Talaromyces marneffei
Primary publication:
Crystal structure of the Mp1p ligand binding domain 2 reveals its function as a fatty acid-binding protein.
Liao S, Tung ET, Zheng W, Chong K, Xu Y, Dai P, Guo Y, Bartlam M, Yuen KY, Rao Z
J Biol Chem 285 9211-20 (2010)
PMID: 20053994

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-128813 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cell wall mannoprotein 1 Chain: A
Molecule details ›
Chain: A
Length: 194 amino acids
Theoretical weight: 21.2 KDa
Source organism: Talaromyces marneffei
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O42721 (Residues: 187-346; Coverage: 36%)
Gene name: MP1
Sequence domains: Hydrophobic surface binding protein A
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand PLM 1 x PLM
1 modified residue:
Ligand MSE 7 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P41212
Unit cell:
a: 46.51Å b: 46.51Å c: 149.38Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.185 0.182 0.198
Expression system: Escherichia coli BL21

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Citations

2 review citations

Applications of isothermal titration calorimetry in pure and applied research--survey of the literature from 2010.
Ghai et al. (2012)
1 more

2 mentions without citation

Talaromyces marneffei Mp1 Protein, a Novel Virulence Factor, Carries Two Arachidonic Acid-Binding Domains To Suppress Inflammatory Responses in Hosts.
Lam et al. (2019)
1 more