› 3l8i

X-ray diffraction
2.5Å resolution

Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity

Released:
DOI: 10.2210/pdb3l8i/pdb
PDB entry 3l8i coloured by chain, front view.
PDB entry 3l8i coloured by chain, side view.
PDB entry 3l8i coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity.
Li X, Zhang R, Zhang H, He Y, Ji W, Min W, Boggon TJ
J Biol Chem 285 24099-107 (2010)
PMID: 20489202

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-189740 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Programmed cell death protein 10 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 214 amino acids
Theoretical weight: 24.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BUL8 (Residues: 1-212; Coverage: 100%)
Gene names: CCM3, PDCD10, TFAR15
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P212121
Unit cell:
a: 63.083Å b: 116.008Å c: 123.038Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.229 0.288
Expression system: Escherichia coli

Quick links

Citations

21 review citations

STRIPAK complexes: structure, biological function, and involvement in human diseases.
Hwang et al. (2014)
20 more

6 mentions without citation

Structure-function analysis of core STRIPAK Proteins: a signaling complex implicated in Golgi polarization.
Kean et al. (2011)
5 more