› 3le4

X-ray diffraction
1.7Å resolution

Crystal structure of the DGCR8 dimerization domain

Released:
DOI: 10.2210/pdb3le4/pdb
PDB entry 3le4 coloured by chain, front view.
PDB entry 3le4 coloured by chain, side view.
PDB entry 3le4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the dimerization domain of DiGeorge critical region 8.
Senturia R, Faller M, Yin S, Loo JA, Cascio D, Sawaya MR, Hwang D, Clubb RT, Guo F
Protein Sci 19 1354-65 (2010)
PMID: 20506313

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186804 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microprocessor complex subunit DGCR8 Chain: A
Molecule details ›
Chain: A
Length: 79 amino acids
Theoretical weight: 8.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WYQ5 (Residues: 275-353; Coverage: 10%)
Gene names: C22orf12, DGCR8, DGCRK6, LP4941
Structure domains: Ubiquitin Ligase Nedd4; Chain: W;

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P43212
Unit cell:
a: 39.952Å b: 39.952Å c: 80.626Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.181 0.213
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Regulation of microRNA biogenesis and its crosstalk with other cellular pathways.
Treiber et al. (2019)
10 more

6 mentions without citation

A Structural View of miRNA Biogenesis and Function.
Leitão et al. (2022)
5 more