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3lex

X-ray diffraction
1.97Å resolution

2F5 Epitope scaffold elicited anti-HIV-1 monoclonal antibody 11F10 in complex with HIV-1 GP41

Released:
Model geometry
Fit model/data
Primary publication:
Elicitation of structure-specific antibodies by epitope scaffolds.
Proc Natl Acad Sci U S A 107 17880-7 (2010)
PMID: 20876137

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-212756 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
11f10 Antibody Heavy Chain Chains: A, H
Molecule details ›
Chains: A, H
Length: 221 amino acids
Theoretical weight: 23.92 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
11f10 Antibody Light Chain Chains: B, L
Molecule details ›
Chains: B, L
Length: 219 amino acids
Theoretical weight: 24.26 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Envelope glycoprotein gp41 Chains: C, P

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P1
Unit cell:
a: 34.543Å b: 70.962Å c: 78.265Å
α: 90.08° β: 90.02° γ: 90.29°
R-values:
R R work R free
0.166 0.165 0.198
Expression system: Not provided