› 3lg0

X-ray diffraction
2.3Å resolution

Structure of Plasmodium falciparum ornithine delta-aminotransferase

Released:
DOI: 10.2210/pdb3lg0/pdb
PDB entry 3lg0 coloured by chain, front view.
PDB entry 3lg0 coloured by chain, side view.
PDB entry 3lg0 coloured by chain, top view.
Source organism: Plasmodium falciparum CDC/Honduras
Primary publication:
Redox regulation of Plasmodium falciparum ornithine δ-aminotransferase.
Jortzik E, Fritz-Wolf K, Sturm N, Hipp M, Rahlfs S, Becker K
J Mol Biol 402 445-59 (2010)
PMID: 20673832

Function and Biology Details

Reaction catalysed: 
L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179854 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ornithine aminotransferase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 422 amino acids
Theoretical weight: 47.18 KDa
Source organism: Plasmodium falciparum CDC/Honduras
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6LFH8 (Residues: 1-414; Coverage: 100%)
Gene names: OAT, PF3D7_0608800, PFF0435w
Sequence domains: Aminotransferase class-III
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 50.53Å b: 106.93Å c: 147.14Å
α: 90° β: 91.28° γ: 90°
R-values:
R R work R free
0.206 0.203 0.25
Expression system: Escherichia coli

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Citations

8 review citations

Proline mechanisms of stress survival.
Liang et al. (2013)
7 more

4 mentions without citation

The Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking Investigations.
Ogungbe et al. (2016)
3 more