› 3lh2

X-ray diffraction
2.65Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-211634 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
4E10_1VI7A_S0_002_N (T88) Chains: S, T, U, V
Molecule details ›
Chains: S, T, U, V
Length: 76 amino acids
Theoretical weight: 8.46 KDa
Source organism: synthetic construct
Expression system: Escherichia coli
Structure domains: Alpha-Beta Plaits
Fv 4E10 heavy chain Chains: H, I, J, K
Molecule details ›
Chains: H, I, J, K
Length: 137 amino acids
Theoretical weight: 14.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
Fv 4E10 light chain Chains: L, M, N, O
Molecule details ›
Chains: L, M, N, O
Length: 114 amino acids
Theoretical weight: 12.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P21
Unit cell:
a: 75.85Å b: 145.95Å c: 78.55Å
α: 90° β: 92.43° γ: 90°
R-values:
R R work R free
0.224 0.222 0.27
Expression system: Escherichia coli

Quick links

Citations

47 review citations

HIV-1 neutralizing antibodies: understanding nature's pathways.
Mascola et al. (2013)
46 more

2 mentions without citation

B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV.
Scheid et al. (2021)
1 more