› 3lhp

X-ray diffraction
2.7Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-211635 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Fv 4E10 heavy chain Chains: H, I
Molecule details ›
Chains: H, I
Length: 137 amino acids
Theoretical weight: 14.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
Fv 4E10 light chain Chains: L, M
Molecule details ›
Chains: L, M
Length: 114 amino acids
Theoretical weight: 12.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
4E10_D0_1ISEA_004_N (T93) Chains: S, T
Molecule details ›
Chains: S, T
Length: 123 amino acids
Theoretical weight: 14.05 KDa
Source organism: synthetic construct
Expression system: Escherichia coli
Structure domains: Ribosome-recycling factor

Ligands and Environments

1 bound ligand:
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P212121
Unit cell:
a: 52.977Å b: 88.623Å c: 149.997Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.247 0.243 0.335
Expression system: Escherichia coli

Quick links

Citations

46 review citations

HIV-1 neutralizing antibodies: understanding nature's pathways.
Mascola et al. (2013)
45 more

8 mentions without citation

Computational Methods in Immunology and Vaccinology: Design and Development of Antibodies and Immunogens.
Guarra et al. (2023)
7 more