› 3lju

X-ray diffraction
1.7Å resolution

Crystal structure of full length centaurin alpha-1 bound with the head group of PIP3

Released:
DOI: 10.2210/pdb3lju/pdb
PDB entry 3lju coloured by chain, front view.
PDB entry 3lju coloured by chain, side view.
PDB entry 3lju coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.
Tong Y, Tempel W, Wang H, Yamada K, Shen L, Senisterra GA, MacKenzie F, Chishti AH, Park HW
Proc Natl Acad Sci U S A 107 20346-51 (2010)
PMID: 21057110

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131097 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Arf-GAP with dual PH domain-containing protein 1 Chain: X
Molecule details ›
Chain: X
Length: 386 amino acids
Theoretical weight: 45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75689 (Residues: 3-370; Coverage: 98%)
Gene names: ADAP1, CENTA1
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ZN 1 x ZN
Ligand IP9 2 x IP9
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 51.727Å b: 66.414Å c: 127.219Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.191 0.231
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Regulation of small GTPases by GEFs, GAPs, and GDIs.
Cherfils et al. (2013)
8 more

7 mentions without citation

Creativity comes from interactions: modules of protein interactions in plants.
Allen et al. (2022)
6 more