› 3llt

X-ray diffraction
2.5Å resolution

Crystal structure of PF14_0431, kinase domain.

Released:
DOI: 10.2210/pdb3llt/pdb
PDB entry 3llt coloured by chain, front view.
PDB entry 3llt coloured by chain, side view.
PDB entry 3llt coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Entry authors: Wernimont AK, Tempel W, Lin YH, Loppnau P, MacKenzie F, Sullivan H, Weadge J, Kozieradzki I, Cossar D, Sinesterra G, Vedadi M, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Bochkarev A, Hui R, Qiu W, Hutchinson A, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184811 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein kinase domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 360 amino acids
Theoretical weight: 42.19 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IL19 (Residues: 534-875; Coverage: 39%)
Gene name: PF3D7_1445400
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand SO4 1 x SO4
Ligand ACT 1 x ACT
Ligand ANP 1 x ANP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P65
Unit cell:
a: 140.081Å b: 140.081Å c: 52.418Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.225 0.223 0.267
Expression system: Escherichia coli

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