› 3lnd

X-ray diffraction
2.82Å resolution

Crystal structure of cadherin-6 EC12 W4A

Released:
DOI: 10.2210/pdb3lnd/pdb
PDB entry 3lnd coloured by chain, front view.
PDB entry 3lnd coloured by chain, side view.
PDB entry 3lnd coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Two-step adhesive binding by classical cadherins.
Harrison OJ, Bahna F, Katsamba PS, Jin X, Brasch J, Vendome J, Ahlsen G, Carroll KJ, Price SR, Honig B, Shapiro L
Nat Struct Mol Biol 17 348-57 (2010)
PMID: 20190754

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161289 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-6 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 207 amino acids
Theoretical weight: 23.03 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P97326 (Residues: 54-260; Coverage: 27%)
Gene name: Cdh6
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

1 bound ligand:
Ligand CA 12 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21
Unit cell:
a: 55.979Å b: 113.555Å c: 67.907Å
α: 90° β: 96.01° γ: 90°
R-values:
R R work R free
0.211 0.207 0.282
Expression system: Escherichia coli

Quick links

Citations

31 review citations

E-cadherin junctions as active mechanical integrators in tissue dynamics.
Lecuit et al. (2015)
30 more

1 mention without citation

Computational model of E-cadherin clustering under force.
Chen et al. (2021)