› 3lni

X-ray diffraction
2.3Å resolution

Crystal structure of E-cadherin EC12 E89A

Released:
DOI: 10.2210/pdb3lni/pdb
PDB entry 3lni coloured by chain, front view.
PDB entry 3lni coloured by chain, side view.
PDB entry 3lni coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Two-step adhesive binding by classical cadherins.
Harrison OJ, Bahna F, Katsamba PS, Jin X, Brasch J, Vendome J, Ahlsen G, Carroll KJ, Price SR, Honig B, Shapiro L
Nat Struct Mol Biol 17 348-57 (2010)
PMID: 20190754

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140757 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 213 amino acids
Theoretical weight: 23.2 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P09803 (Residues: 157-369; Coverage: 25%)
Gene name: Cdh1
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

1 bound ligand:
Ligand CA 6 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: C2
Unit cell:
a: 119.63Å b: 77.122Å c: 71.675Å
α: 90° β: 115.25° γ: 90°
R-values:
R R work R free
0.169 0.166 0.228
Expression system: Escherichia coli

Quick links

Citations

31 review citations

E-cadherin junctions as active mechanical integrators in tissue dynamics.
Lecuit et al. (2015)
30 more

5 mentions without citation

Chemical exchange in biomacromolecules: past, present, and future.
Palmer AG. (2014)
4 more