› 3lqw

X-ray diffraction
1.3Å resolution

Crystal structure of deoxyuridine 5-triphosphate nucleotidohydrolase from Entamoeba histolytica

Released:
DOI: 10.2210/pdb3lqw/pdb
PDB entry 3lqw coloured by chain, front view.
PDB entry 3lqw coloured by chain, side view.
PDB entry 3lqw coloured by chain, top view.
Source organism: Entamoeba histolytica HM-1:IMSS
Entry author: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Function and Biology Details

Reaction catalysed: 
dUTP + H(2)O = dUMP + diphosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-111341 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Deoxyuridine 5'-triphosphate nucleotidohydrolase Chain: A
Molecule details ›
Chain: A
Length: 163 amino acids
Theoretical weight: 18.01 KDa
Source organism: Entamoeba histolytica HM-1:IMSS
Expression system: Escherichia coli
UniProt:
  • Canonical: C4M4M6 (Residues: 1-142; Coverage: 100%)
Gene name: EHI_189420
Sequence domains: dUTPase
Structure domains: Deoxyuridine 5'-Triphosphate Nucleotidohydrolase; Chain A

Ligands and Environments

2 bound ligands:
Ligand EDO 1 x EDO
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: R3
Unit cell:
a: 63.14Å b: 63.14Å c: 108.37Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.133 0.132 0.155
Expression system: Escherichia coli

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