› 3lx3

X-ray diffraction
1.55Å resolution

Plasmodium vivax 6-pyruvoyltetrahydropterin synthase (PTPS) in complex with xanthopterin

Released:
DOI: 10.2210/pdb3lx3/pdb
PDB entry 3lx3 coloured by chain, front view.
PDB entry 3lx3 coloured by chain, side view.
PDB entry 3lx3 coloured by chain, top view.
Source organism: Plasmodium vivax
Entry authors: Larson ET, Merritt EA, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)

Function and Biology Details

Reaction catalysed: 
7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107660 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
6-pyruvoyltetrahydropterin synthase Chain: A
Molecule details ›
Chain: A
Length: 180 amino acids
Theoretical weight: 20.99 KDa
Source organism: Plasmodium vivax
Expression system: Escherichia coli
UniProt:
  • Canonical: A5K2B2 (Residues: 1-172; Coverage: 100%)
Gene name: PVX_114505
Sequence domains: 6-pyruvoyl tetrahydropterin synthase
Structure domains: 6-pyruvoyl tetrahydropterin synthase/QueD

Ligands and Environments

2 bound ligands:
Ligand ZN 1 x ZN
Ligand XTN 1 x XTN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: R32
Unit cell:
a: 131.358Å b: 131.358Å c: 73.577Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.15 0.149 0.167
Expression system: Escherichia coli

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