› 3lxj

X-ray diffraction
2.33Å resolution

Crystal Structure of the Bromodomain of Human AAA domain containing 2B (ATAD2B)

Released:
DOI: 10.2210/pdb3lxj/pdb
PDB entry 3lxj coloured by chain, front view.
PDB entry 3lxj coloured by chain, side view.
PDB entry 3lxj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Histone recognition and large-scale structural analysis of the human bromodomain family.
Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Müller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S
Cell 149 214-31 (2012)
PMID: 22464331

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193921 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATPase family AAA domain-containing protein 2B Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 136 amino acids
Theoretical weight: 15.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9ULI0 (Residues: 952-1086; Coverage: 9%)
Gene names: ATAD2B, KIAA1240
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand IPA 5 x IPA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P65
Unit cell:
a: 79.64Å b: 79.64Å c: 204.051Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.214 0.212 0.253
Expression system: Escherichia coli

Quick links

Citations

245 review citations

Modification of enhancer chromatin: what, how, and why?
Calo et al. (2013)
244 more

7 mentions without citation

Biological function and histone recognition of family IV bromodomain-containing proteins.
Lloyd et al. (2018)
6 more