› 3m52

X-ray diffraction
2.59Å resolution

Crystal structure of the BTB domain from the Miz-1/ZBTB17 transcription regulator

Released:
DOI: 10.2210/pdb3m52/pdb
PDB entry 3m52 coloured by chain, front view.
PDB entry 3m52 coloured by chain, side view.
PDB entry 3m52 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Insights into strand exchange in BTB domain dimers from the crystal structures of FAZF and Miz1.
Stogios PJ, Cuesta-Seijo JA, Chen L, Pomroy NC, Privé GG
J Mol Biol 400 983-97 (2010)
PMID: 20493880

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171531 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Zinc finger and BTB domain-containing protein 17 Chains: A, B
Molecule details ›
Chains: A, B
Length: 117 amino acids
Theoretical weight: 12.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13105 (Residues: 1-115; Coverage: 14%)
Gene names: MIZ1, ZBTB17, ZNF151, ZNF60
Sequence domains: BTB/POZ domain
Structure domains: Potassium Channel Kv1.1; Chain A

Ligands and Environments

2 bound ligands:
Ligand ZN 6 x ZN
Ligand ACT 2 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 33.023Å b: 80.935Å c: 95.713Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.225 0.266
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Regulation of hematopoietic development by ZBTB transcription factors.
Maeda T. (2016)
12 other articles

3 mentions without citation

Structures of heterodimeric POZ domains of Miz1/BCL6 and Miz1/NAC1.
Stead et al. (2014)
2 more