› 3m8o

X-ray diffraction
1.55Å resolution

Human IgA1 Fab fragment

Released:
DOI: 10.2210/pdb3m8o/pdb
PDB entry 3m8o coloured by chain, front view.
PDB entry 3m8o coloured by chain, side view.
PDB entry 3m8o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of a human IgA1 Fab fragment at 1.55 Å resolution: potential effect of the constant domains on antigen-affinity modulation.
Correa A, Trajtenberg F, Obal G, Pritsch O, Dighiero G, Oppezzo P, Buschiazzo A
Acta Crystallogr D Biol Crystallogr 69 388-97 (2013)
PMID: 23519414

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-234871 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
IMMUNOGLOBULIN A1 LIGHT CHAIN Chain: L
Molecule details ›
Chain: L
Length: 219 amino acids
Theoretical weight: 24.01 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
IMMUNOGLOBULIN A1 HEAVY CHAIN Chain: H
Molecule details ›
Chain: H
Length: 221 amino acids
Theoretical weight: 23.51 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand CL 5 x CL
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21
Unit cell:
a: 43.78Å b: 76.3Å c: 55.85Å
α: 90° β: 105.48° γ: 90°
R-values:
R R work R free
0.154 0.153 0.182

Quick links

Citations

6 review citations

Ig Constant Region Effects on Variable Region Structure and Function.
Janda et al. (2016)
5 more

8 mentions without citation

Systematic screening of soluble expression of antibody fragments in the cytoplasm of E. coli.
Gaciarz et al. (2016)
7 more