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› 3m9s

X-ray diffraction
4.5Å resolution

Crystal structure of respiratory complex I from Thermus thermophilus

Released:
DOI: 10.2210/pdb3m9s/pdb
Model geometry
Fit model/data
Data not analysed
PDB entry 3m9s coloured by chain, front view.
PDB entry 3m9s coloured by chain, side view.
PDB entry 3m9s coloured by chain, top view.
Source organism: Thermus thermophilus HB8
Primary publication:
The architecture of respiratory complex I.
Efremov RG, Baradaran R, Sazanov LA
Nature 465 441-5 (2010)
PMID: 20505720

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tridecamer (preferred)
PDBe Complex ID:
PDB-CPX-163776 (preferred)
Entry contents:
13 distinct polypeptide molecules
Macromolecules (13 distinct):
NADH-quinone oxidoreductase subunit 1 Chains: 1, A
Molecule details ›
Chains: 1, A
Length: 438 amino acids
Theoretical weight: 48.69 KDa
Source organism: Thermus thermophilus HB8
UniProt:
  • Canonical: Q56222 (Residues: 1-438; Coverage: 100%)
Gene names: TTHA0089, nqo1
Sequence domains:
NADH-quinone oxidoreductase subunit 2 Chains: 2, B
Molecule details ›
Chains: 2, B
Length: 181 amino acids
Theoretical weight: 20.31 KDa
Source organism: Thermus thermophilus HB8
UniProt:
  • Canonical: Q56221 (Residues: 1-181; Coverage: 100%)
Gene names: TTHA0088, nqo2
Sequence domains: Thioredoxin-like [2Fe-2S] ferredoxin
NADH-quinone oxidoreductase subunit 3 Chains: 3, C
NADH-quinone oxidoreductase subunit 4 Chains: 4, D
NADH-quinone oxidoreductase subunit 5 Chains: 5, E
NADH-quinone oxidoreductase subunit 6 Chains: 6, F
NADH-quinone oxidoreductase subunit 9 Chains: 9, G
NADH-quinone oxidoreductase subunit 15 Chains: 7, J
NADH-quinone oxidoreductase subunit 12 Chains: L, O
NADH-quinone oxidoreductase subunit 13 Chains: M, P
NADH-quinone oxidoreductase subunit 14 Chains: N, Q
NADH-quinone oxidoreductase subunits 7, 10 and 11 Chains: R, S
NADH-quinone oxidoreductase subunit 8 Chains: H, T

Ligands and Environments

3 bound ligands:
Ligand SF4 14 x SF4
Ligand FMN 2 x FMN
Ligand FES 4 x FES
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 96.39Å b: 336.09Å c: 262.24Å
α: 90° β: 100.59° γ: 90°

Quick links

Citations

81 review citations

Molecular aspects of bacterial pH sensing and homeostasis.
Krulwich et al. (2011)
80 more

21 mentions without citation

The role of mitochondrial function and cellular bioenergetics in ageing and disease.
Brand et al. (2013)
20 more