› 3mb3

X-ray diffraction
2.25Å resolution

Crystal Structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP)

Released:
DOI: 10.2210/pdb3mb3/pdb
PDB entry 3mb3 coloured by chain, front view.
PDB entry 3mb3 coloured by chain, side view.
PDB entry 3mb3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Histone recognition and large-scale structural analysis of the human bromodomain family.
Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Müller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S
Cell 149 214-31 (2012)
PMID: 22464331

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186760 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PH-interacting protein Chain: A
Molecule details ›
Chain: A
Length: 135 amino acids
Theoretical weight: 16.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8WWQ0 (Residues: 1302-1434; Coverage: 7%)
Gene names: DCAF14, PHIP, WDR11
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand MB3 1 x MB3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P3121
Unit cell:
a: 92.09Å b: 92.09Å c: 76.12Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.208 0.206 0.257
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

245 review citations

Modification of enhancer chromatin: what, how, and why?
Calo et al. (2013)
244 more

8 mentions without citation

Druggability analysis and structural classification of bromodomain acetyl-lysine binding sites.
Vidler et al. (2012)
7 more