› 3mbg

X-ray diffraction
1.85Å resolution

Crystal Structure of Human Augmenter of Liver Regeneration (ALR)

Released:
DOI: 10.2210/pdb3mbg/pdb
PDB entry 3mbg coloured by chain, front view.
PDB entry 3mbg coloured by chain, side view.
PDB entry 3mbg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the human sulfhydryl oxidase augmenter of liver regeneration and characterization of a human mutation causing an autosomal recessive myopathy .
Daithankar VN, Schaefer SA, Dong M, Bahnson BJ, Thorpe C
Biochemistry 49 6737-45 (2010)
PMID: 20593814

Function and Biology Details

Reaction catalysed: 
2 R'C(R)SH + O(2) = R'C(R)S-S(R)CR' + H(2)O(2)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157316 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
FAD-linked sulfhydryl oxidase ALR Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 139 amino acids
Theoretical weight: 16.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P55789 (Residues: 81-205; Coverage: 61%)
Gene names: ALR, GFER, HERV1, HPO
Sequence domains: Erv1 / Alr family
Structure domains: ERV/ALR sulfhydryl oxidase domain

Ligands and Environments


Cofactor: Ligand FAD 3 x FAD
3 bound ligands:
Ligand ZN 10 x ZN
Ligand NA 4 x NA
Ligand ACT 11 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: C2
Unit cell:
a: 112.719Å b: 65.145Å c: 63.767Å
α: 90° β: 89.97° γ: 90°
R-values:
R R work R free
0.191 0.189 0.231
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

13 review citations

Mitochondrial disulfide relay: redox-regulated protein import into the intermembrane space.
Herrmann et al. (2012)
12 more

5 mentions without citation

Structure of the human sulfhydryl oxidase augmenter of liver regeneration and characterization of a human mutation causing an autosomal recessive myopathy .
Daithankar et al. (2010)
4 more