› 3mce

X-ray diffraction
2.4Å resolution

Crystal structure of the NAC domain of alpha subunit of nascent polypeptide-associated complex(NAC)

Released:
DOI: 10.2210/pdb3mce/pdb
PDB entry 3mce coloured by chain, front view.
PDB entry 3mce coloured by chain, side view.
PDB entry 3mce coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of NAC domains of human nascent polypeptide-associated complex (NAC) and its αNAC subunit.
Wang L, Zhang W, Wang L, Zhang XC, Li X, Rao Z
Protein Cell 1 406-416 (2010)
PMID: 21203952

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171816 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nascent polypeptide-associated complex subunit alpha Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 61 amino acids
Theoretical weight: 6.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13765 (Residues: 81-133; Coverage: 25%)
Gene names: HSD48, NACA
Sequence domains: NAC domain

Ligands and Environments

1 bound ligand:
Ligand IOD 8 x IOD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P21212
Unit cell:
a: 54.592Å b: 59.605Å c: 69.13Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.25 0.247 0.277
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Chaperone Interactions at the Ribosome.
Deuerling et al. (2019)
2 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)