Function and Biology Details
Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Transcription factor, enhancer of yellow 2
- Zinc finger, UBP-type
- SAGA complex, Sgf11 subunit
- Ubiquitin specific protease, conserved site
- SAGA-associated factor 73, zinc finger domain
- SAGA-associated factor 73
- Yeast SAGA-associated factor 11, N-terminal domain
- Transcription factor EnY2 superfamily
4 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-156126 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Ubiquitin carboxyl-terminal hydrolase 8
Molecule details ›
Chain: A
Length: 476 amino acids
Theoretical weight: 54.03 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains:
Length: 476 amino acids
Theoretical weight: 54.03 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
- Canonical:
P50102 (Residues: 1-471; Coverage: 100%)
Sequence domains:
Structure domains:
Transcription and mRNA export factor SUS1
Molecule details ›
Chain: B
Length: 96 amino acids
Theoretical weight: 11.09 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
Sequence domains: Transcription factor e(y)2
Structure domains: Serum Albumin; Chain A, Domain 1
Length: 96 amino acids
Theoretical weight: 11.09 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
- Canonical: Q6WNK7 (Residues: 1-96; Coverage: 100%)
Sequence domains: Transcription factor e(y)2
Structure domains: Serum Albumin; Chain A, Domain 1
SAGA-associated factor 11
Molecule details ›
Chain: C
Length: 99 amino acids
Theoretical weight: 11.3 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains:
Length: 99 amino acids
Theoretical weight: 11.3 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
- Canonical: Q03067 (Residues: 1-99; Coverage: 100%)
Sequence domains:
Structure domains:
SAGA-associated factor 73
Molecule details ›
Chain: E
Length: 96 amino acids
Theoretical weight: 10.82 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
Sequence domains: Zinc finger domain
Length: 96 amino acids
Theoretical weight: 10.82 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
- Canonical: P53165 (Residues: 1-96; Coverage: 15%)
Sequence domains: Zinc finger domain
