› 3mij

X-ray diffraction
2.6Å resolution

Crystal structure of a telomeric RNA G-quadruplex complexed with an acridine-based ligand.

Released:
DOI: 10.2210/pdb3mij/pdb
PDB entry 3mij coloured by chain, front view.
PDB entry 3mij coloured by chain, side view.
PDB entry 3mij coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of telomeric RNA quadruplex--acridine ligand recognition.
Collie GW, Sparapani S, Parkinson GN, Neidle S
J Am Chem Soc 133 2721-8 (2011)
PMID: 21291211

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196701 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
RNA (5'-R(*UP*AP*GP*GP*GP*UP*UP*AP*GP*GP*GP*U)-3') Chain: A
Molecule details ›
Chain: A
Length: 12 nucleotides
Theoretical weight: 3.91 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand K 2 x K
Ligand R14 1 x R14
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P23
Unit cell:
a: 56.606Å b: 56.606Å c: 56.606Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.235 0.248
Expression system: Not provided

Quick links

Citations

19 review citations

5'-UTR RNA G-quadruplexes: translation regulation and targeting.
Bugaut et al. (2012)
18 more

12 mentions without citation

Targeting RNA with small molecules: from fundamental principles towards the clinic.
Falese et al. (2021)
11 more