› 3ms6

X-ray diffraction
2.08Å resolution

Crystal structure of Hepatitis B X-Interacting Protein (HBXIP)

Released:
DOI: 10.2210/pdb3ms6/pdb
PDB entry 3ms6 coloured by chain, front view.
PDB entry 3ms6 coloured by chain, side view.
PDB entry 3ms6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural characterization of HBXIP: the protein that interacts with the anti-apoptotic protein survivin and the oncogenic viral protein HBx.
Garcia-Saez I, Lacroix FB, Blot D, Gabel F, Skoufias DA
J Mol Biol 405 331-40 (2011)
PMID: 21059355

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128948 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ragulator complex protein LAMTOR5 Chain: A
Molecule details ›
Chain: A
Length: 99 amino acids
Theoretical weight: 10.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O43504 (Residues: 1-91; Coverage: 100%)
Gene names: HBXIP, LAMTOR5, XIP
Sequence domains: Ragulator complex protein LAMTOR5
Structure domains: Dynein light chain 2a, cytoplasmic

Ligands and Environments

3 bound ligands:
Ligand PEG 1 x PEG
Ligand IPA 2 x IPA
Ligand GOL 1 x GOL
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P41212
Unit cell:
a: 48.997Å b: 48.997Å c: 71.644Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.191 0.228
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Amino acid signalling upstream of mTOR.
Jewell et al. (2013)
2 more

3 mentions without citation

Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling.
Powis et al. (2015)
2 more