› 3mtl

X-ray diffraction
2.4Å resolution

Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804

Released:
DOI: 10.2210/pdb3mtl/pdb
PDB entry 3mtl coloured by chain, front view.
PDB entry 3mtl coloured by chain, side view.
PDB entry 3mtl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16.
Dixon-Clarke SE, Shehata SN, Krojer T, Sharpe TD, von Delft F, Sakamoto K, Bullock AN
Biochem J 474 699-713 (2017)
PMID: 28057719

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-169445 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase 16 Chain: A
Molecule details ›
Chain: A
Length: 324 amino acids
Theoretical weight: 37.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q00536 (Residues: 163-478; Coverage: 64%)
Gene names: CDK16, PCTAIRE1, PCTK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand FEF 1 x FEF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P43212
Unit cell:
a: 47.39Å b: 47.39Å c: 341.31Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.194 0.263
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Structural insights into the functional diversity of the CDK-cyclin family.
Wood et al. (2018)
3 more

9 mentions without citation

Orphan kinases turn eccentric: a new class of cyclin Y-activated, membrane-targeted CDKs.
Mikolcevic et al. (2012)
8 more